Data science concepts and considerations in conducting and interpreting exposome-wide association studies.
Abstract
Central to the exposome concept includes data-driven and comprehensive approaches to identify individuals and mixtures of correlates with disease and health outcomes. Here, we attempt to offer a guide for new researchers on how to interpret and evaluate data-driven exposomic studies. We first introduce the concepts of contributions from genes and environment to phenotypes and data-driven analysis in large observation cohorts. We then give an overview of exposome-wide association studies (ExWAS), a versatile analytical approach to identify robust signals from large and complex exposomic data, and discuss their key considerations and extensions. We also briefly cover emerging topics for exposmic studies, including FAIR Data Principles, administrative healthcare datasets, and functional exposomic data. Finally, for any data-driven study associating multiple exposures with a phenotype and involving correction for multiple comparisons, regardless of data types and research questions, we propose to standardize the terminology for this approach as "exposome-wide association study, ExWAS”. This will facilitate effective communication among researchers and improve literature retrieval.
Author List
Members of the Exposomics Consortium*
The Exposomics Consortium consists of participants in the NIEHS Catalytic Workshop Series on the Exposome. *Members were required to opt-in to the roster below.
| Name | Institution | Country |
|---|---|---|
| ADAMU, Yau | University of Iowa | United States |
| ADEBAMOWO, Clement (Prof.) | University of Maryland at Baltimore | United States |
| AKHTARI, Farida (Ph.D.) | NIEHS | United States |
| AKHTARI, Farida (Ph.D.) | NIEHS | United States |
| ARGOS, Maria (Ph.D.) | Boston University | United States |
| ARUNACHALAM, Saravanan (Prof.) | University of North Carolina at Chapel Hill | United States |
| BAUMERT, Brittney (Ph.D.) | University of Southern California | United States |
| BEGLARIAN, Emily (Ms.) | University of Southern California | United States |
| BERGER, Kimberly (Ph.D.) | Sequoia Foundation | United States |
| BHUTANI, Jessie | NIH | United States |
| BISSON, William (Ph.D.) | NIEHS | United States |
| BRETON, Carrie | University of Southern California | United States |
| CAI, Lu (M.D.,Ph.D.) | University of Louisville | United States |
| CHAO, Mu-rong (Prof.) | Chung Shan Medical University | Taiwan |
| CHATZIIOANNOU, Anastasia Chrysovalantou (Ph.D.) | University of Crete | Greece |
| CHENG, Qiwen | Arizona State University, Tempe Campus | United States |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| CHUNG, Ming Kei (Ph.D.) | Harvard University | United States |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| CLARK, Robert (Ph.D.) | RTI International | United States |
| COHEN HUBAL, Elaine | EPA | United States |
| CONTI, David (Ph.D.) | University of Southern California | United States |
| COOKE, Marcus (Ph.D.) | University of South Florida | United States |
| COSTELLO, Elizabeth | University of Southern California | United States |
| CUI, Yuxia (Ph.D.) | NIEHS | United States |
| DIERICKX, Erin (Ms.) | University of Connecticut | United States |
| DOLINOY, Dana (Ph.D.) | University of Michigan - Ann Arbor | United States |
| DU, Xiuxia (Prof.) | University of North Carolina at Charlotte | United States |
| ENGEL, Lawrence (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| GAO, Peng (Prof.) | University of Pittsburgh | United States |
| GAULKE, Christopher (Ph.D.) | University of Illinois at Urbana-Champaign | United States |
| GIEBELHAUS, Ryland T. (Mr.) | University of Alberta | Canada |
| GOODRICH, Jesse (Ph.D.) | University of Southern California | United States |
| GRAFANAKI, Katerina (M.D.,Ph.D.) | University of Patras | Greece |
| GULLAPALLI, Rama (M.D.,Ph.D.) | University of New Mexico | United States |
| HABRE, Rima (Sc.D.) | University of Southern California | United States |
| HAIDARI, Ariana | University of Michigan - Ann Arbor | United States |
| HARARI, Homero (Ph.D.) | Mount Sinai School of Medicine | United States |
| HART, Jaime (Sc.D.) | Harvard University | United States |
| HE, Jingxuan | University of Southern California | United States |
| HOLMES, Philip | NCIT | United States |
| HOOD, Darryl B. (Ph.D.) | Ohio State University | United States |
| HOUSE, John (M.D.,Ph.D.) | NIEHS | United States |
| HU, Chiung-wen (Prof.) | Chung Shan Medical University | Taiwan |
| HU, Hui (Ph.D.) | Harvard University | United States |
| JAMES, Peter (Sc.D.) | Harvard University | United States |
| JANKOWSKA, Marta (Ph.D.) | Beckman Research Institute, City of Hope | United States |
| JI, Hong (Ph.D.) | University of California, Davis | United States |
| KANNAN, Srimathik@gmail.com (Ph.D.) | CloudAspirers | United States |
| KONSTANTINOU, Corina (Ms.) | Cyprus University of Technology | Cyprus |
| LAI, Yunjia (Ph.D.) | Columbia University | United States |
| LANGSTON, Mike (Prof.) | University of Tennessee - Knoxville | United States |
| LASALLE, Janine (Ph.D.) | University of California, Davis | United States |
| LEANG, Amy | University of Washington | United States |
| LIANG, Donghai (Ph.D.) | Emory University | United States |
| LIAO, Jiawen (Ph.D.) | University of Southern California | United States |
| LUO, Jiajun (Ph.D.) | University of Chicago | United States |
| MAKRIS, Konstantinos C. (Prof.) | Cyprus University of Technology | Cyprus |
| MANZ, Katherine | University of Michigan - Ann Arbor | United States |
| MILLER, Gary (Ph.D.) | Columbia University | United States |
| MOTSINGER-REIF, Alison (Ph.D.) | NIEHS | United States |
| OUIDIR, Marion | INSERM | France |
| PAGE, Grier (Ph.D.) | RTI International | United States |
| PAN, Shudi | University of Southern California | United States |
| PARKER, Graham (Ph.D.) | Wayne State University / School of Medicine | Canada |
| PAUL, Kimberly (Ph.D.) | University of California, Los Angeles | United States |
| PELUSO, Alina | DOE | United States |
| PENNING, Trevor (Ph.D.) | University of Pennsylvania | United States |
| PIERCE, Brandon | University of Chicago | United States |
| PRAJAPATI, Nirmala (Ms.) | Universite Paris-Saclay/ INSERM | France |
| PRINS, Gail (Ph.D.) | University of Illinois at Chicago | United States |
| QUINTANA, Penelope J E (Ph.D.) | San Diego State University | United States |
| RAJASEKAR, Arcot (raja) (Prof.) | University of North Carolina at Chapel Hill | United States |
| RAMESH, Aramandla (Ph.D.) | Meharry Medical College | United States |
| RUDEN, Douglas (Ph.D.) | Wayne State University | United States |
| RUSHING, Blake (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| SCHOLL, Elizabeth (Ph.D.) | Sciome LLC | United States |
| SCHüSSLER-FIORENZA ROSE, Sophia Miryam (M.D.,Ph.D.) | Standford University | United States |
| SHAH, Ruchir (Ph.D.) | Sciome LLC | United States |
| SHAHRIAR, Mohammad (M.D.) | University of Chicago | United States |
| SIWAKOTI, Ram (Mr.) | University of Michigan - Ann Arbor | United States |
| SOARES, Lissa | State University of New York at Stony Brook | United States |
| SOLIMAN, Ghada (Ph.D.) | City University of New York, Graduate School and University Center | United States |
| STATES, J Christopher (Ph.D.) | University of Louisville | United States |
| STINGONE, Jeanette | Columbia University | United States |
| STURLA IRIZARRY, Savannah (Ms.) | University of Michigan - Ann Arbor | United States |
| SUN, Yangbo | University of Tennessee - Memphis | United States |
| SUNDSETH, Scott (Ph.D.) | International HundredK+ Cohorts Consortium | United States |
| TEITELBAUM, Susan (Ph.D.) | Icahn School of Medicine at Mount Sinai | United States |
| THESSEN, Anne (Ph.D.) | University of Colorado at Denver | United States |
| TONG, Ai Phuong | University of Washington | United States |
| VIJAYAKUMAR, Nisha | University of South Florida | United States |
| WALKER, Ryan (Ph.D.) | Mount Sinai School of Medicine | United States |
| WANG, Yi (M.D.,Ph.D.) | Canadian Nuclear Laboratories | Canada |
| WHYTE, Kathryn (Ph.D.) | Columbia University | United States |
| WILSON, Ander (Ph.D.) | Colorado State University | United States |
| WU, K. Lily (Ph.D.) | California Environmental Protection Agency | United States |
| WU, Lang (Prof.) | University of Hawaii - Manoa | United States |
| YUAN, Xin/jean (Ph.D.) | NIH | United States |
| ZHANG, Xinyue (Ph.D.) | Stanford University | United States |
| ZHANG, Qiong | Henry Ford Health System | United States |
| ZHAO, Neil | University of Michigan - Ann Arbor | United States |
| ZHU, Yeyi | Kaiser Permanente Northern California Division of Research | United States |