A roadmap to advance exposomics through federation of data.
Abstract
The scale of the human exposome, which covers all environmental exposures encountered from conception to death, presents major challenges in managing, sharing, and integrating a myriad of relevant data types and available data sets for the benefit of exposomics research and public health. By addressing these challenges, the exposomics research community will be able to greatly expand on its ability to aggregate study data for new discoveries, construct and update novel exposomics data sets for building artificial intelligence and machine learning-based models, rapidly survey emerging issues, and advance the application of data-driven science. The diversity of the field, which spans multiple subfields of science disciplines and different environmental contexts, necessitates adopting data federation approaches to bridge between numerous geographically and administratively separated data resources that have varying usage, privacy, access, analysis, and discoverability capabilities and constraints. This paper presents use cases, challenges, opportunities, and recommendations for the exposomics community to establish and mature a federated exposomics data ecosystem.
Author List
Members of the Exposomics Consortium*
The Exposomics Consortium consists of participants in the NIEHS Catalytic Workshop Series on the Exposome. *Members were required to opt-in to the roster below.
| Name | Institution | Country |
|---|---|---|
| ADAMU, Yau | University of Iowa | United States |
| ADAR, Sara D. (Sc.D.) | University of Michigan - Ann Arbor | United States |
| ADEBAMOWO, Clement (Prof.) | University of Maryland at Baltimore | United States |
| AKHTARI, Farida (Ph.D.) | NIEHS | United States |
| AKHTARI, Farida (Ph.D.) | NIEHS | United States |
| ARGOS, Maria (Ph.D.) | Boston University | United States |
| ARUNACHALAM, Saravanan (Prof.) | University of North Carolina at Chapel Hill | United States |
| BERGER, Kimberly (Ph.D.) | Sequoia Foundation | United States |
| BHUTANI, Jessie | NIH | United States |
| CAI, Lu (M.D.,Ph.D.) | University of Louisville | United States |
| CHAO, Mu-rong (Prof.) | Chung Shan Medical University | Taiwan |
| CHATZIIOANNOU, Anastasia Chrysovalantou (Ph.D.) | University of Crete | Greece |
| CHENG, Qiwen | Arizona State University, Tempe Campus | United States |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| CHUNG, Ming Kei (Ph.D.) | Harvard University | United States |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| CLARK, Robert (Ph.D.) | RTI International | United States |
| COHEN HUBAL, Elaine | EPA | United States |
| COOKE, Marcus (Ph.D.) | University of South Florida | United States |
| COSTELLO, Elizabeth | University of Southern California | United States |
| CUI, Yuxia (Ph.D.) | NIEHS | United States |
| DIERICKX, Erin (Ms.) | University of Connecticut | United States |
| DOLINOY, Dana (Ph.D.) | University of Michigan - Ann Arbor | United States |
| DU, Xiuxia (Prof.) | University of North Carolina at Charlotte | United States |
| FECHO, Karamarie (Ph.D.) | Copperline Professional Solutions, LLC | United States |
| GAO, Peng (Prof.) | University of Pittsburgh | United States |
| GAULKE, Christopher (Ph.D.) | University of Illinois at Urbana-Champaign | United States |
| GIEBELHAUS, Ryland T. (Mr.) | University of Alberta | Canada |
| GOODRICH, Jesse (Ph.D.) | University of Southern California | United States |
| GRAFANAKI, Katerina (M.D.,Ph.D.) | University of Patras | Greece |
| GULLAPALLI, Rama (M.D.,Ph.D.) | University of New Mexico | United States |
| HABRE, Rima (Sc.D.) | University of Southern California | United States |
| HANSON, Heidi (Ph.D.) | DOE | United States |
| HARARI, Homero (Ph.D.) | Mount Sinai School of Medicine | United States |
| HART, Jaime (Sc.D.) | Harvard University | United States |
| HE, Jingxuan | University of Southern California | United States |
| HOLMES, Philip | NCIT | United States |
| HOOD, Darryl B. (Ph.D.) | Ohio State University | United States |
| HOUSE, John (M.D.,Ph.D.) | NIEHS | United States |
| HU, Chiung-wen (Prof.) | Chung Shan Medical University | Taiwan |
| HU, Hui (Ph.D.) | Harvard University | United States |
| HUA, Jenna (Ph.D.) | Million Marker | United States |
| JAMES, Peter (Sc.D.) | Harvard University | United States |
| JANKOWSKA, Marta (Ph.D.) | Beckman Research Institute, City of Hope | United States |
| JI, Hong (Ph.D.) | University of California, Davis | United States |
| KANNAN, Srimathik@gmail.com (Ph.D.) | CloudAspirers | United States |
| KONSTANTINOU, Corina (Ms.) | Cyprus University of Technology | Cyprus |
| LAI, Yunjia (Ph.D.) | Columbia University | United States |
| LANGSTON, Mike (Prof.) | University of Tennessee - Knoxville | United States |
| LASALLE, Janine (Ph.D.) | University of California, Davis | United States |
| LIANG, Donghai (Ph.D.) | Emory University | United States |
| LIAO, Jiawen (Ph.D.) | University of Southern California | United States |
| LUO, Jiajun (Ph.D.) | University of Chicago | United States |
| MAKRIS, Konstantinos C. (Prof.) | Cyprus University of Technology | Cyprus |
| MANZ, Katherine | University of Michigan - Ann Arbor | United States |
| MILLER, Gary (Ph.D.) | Columbia University | United States |
| MOTSINGER-REIF, Alison (Ph.D.) | NIEHS | United States |
| NOREN HOOTEN, Nicole (Ph.D.) | NIH | United States |
| OUIDIR, Marion | INSERM | France |
| PAGE, Grier (Ph.D.) | RTI International | United States |
| PAN, Shudi | University of Southern California | United States |
| PARKER, Graham (Ph.D.) | Wayne State University / School of Medicine | Canada |
| PAUL, Kimberly (Ph.D.) | University of California, Los Angeles | United States |
| PELUSO, Alina | DOE | United States |
| PENNING, Trevor (Ph.D.) | University of Pennsylvania | United States |
| PIERCE, Brandon | University of Chicago | United States |
| PRAJAPATI, Nirmala (Ms.) | Universite Paris-Saclay/ INSERM | France |
| QUINTANA, Penelope J E (Ph.D.) | San Diego State University | United States |
| RAJASEKAR, Arcot (raja) (Prof.) | University of North Carolina at Chapel Hill | United States |
| RAMESH, Aramandla (Ph.D.) | Meharry Medical College | United States |
| RUDEN, Douglas (Ph.D.) | Wayne State University | United States |
| RUSHING, Blake (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| SCHMITT, Charles (Ph.D.) | NIEHS | United States |
| SCHOLL, Elizabeth (Ph.D.) | Sciome LLC | United States |
| SCHüSSLER-FIORENZA ROSE, Sophia Miryam (M.D.,Ph.D.) | Standford University | United States |
| SHAH, Ruchir (Ph.D.) | Sciome LLC | United States |
| SHAHRIAR, Mohammad (M.D.) | University of Chicago | United States |
| SOARES, Lissa | State University of New York at Stony Brook | United States |
| SOLIMAN, Ghada (Ph.D.) | City University of New York, Graduate School and University Center | United States |
| STANEK, Lindsay | EPA | United States |
| STATES, J Christopher (Ph.D.) | University of Louisville | United States |
| STURLA IRIZARRY, Savannah (Ms.) | University of Michigan - Ann Arbor | United States |
| SUN, Yangbo | University of Tennessee - Memphis | United States |
| SUNDSETH, Scott (Ph.D.) | International HundredK+ Cohorts Consortium | United States |
| TEITELBAUM, Susan (Ph.D.) | Icahn School of Medicine at Mount Sinai | United States |
| TONG, Ai Phuong | University of Washington | United States |
| VIJAYAKUMAR, Nisha | University of South Florida | United States |
| WALKER, Ryan (Ph.D.) | Mount Sinai School of Medicine | United States |
| WANG, Yi (M.D.,Ph.D.) | Canadian Nuclear Laboratories | Canada |
| WHYTE, Kathryn (Ph.D.) | Columbia University | United States |
| WILSON, Ander (Ph.D.) | Colorado State University | United States |
| WU, K. Lily (Ph.D.) | California Environmental Protection Agency | United States |
| WU, Lang (Prof.) | University of Hawaii - Manoa | United States |
| YUAN, Xin/jean (Ph.D.) | NIH | United States |
| ZHANG, Xinyue (Ph.D.) | Stanford University | United States |
| ZHANG, Qiong | Henry Ford Health System | United States |
| ZHAO, Neil | University of Michigan - Ann Arbor | United States |