The Exposome and Nutritional Pharmacology and Toxicology: A New Application for Metabolomics.
Abstract
The exposome refers to all of the internal and external life-long exposures that an individual experiences. These exposures, either acute or chronic, are associated with changes in metabolism that will positively or negatively influence the health and well-being of individuals. Nutrients and other dietary compounds modulate similar biochemical processes and have the potential in some cases to counteract the negative effects of exposures or enhance their beneficial effects. We present herein the concept of Nutritional Pharmacology/Toxicology which uses high-information metabolomics workflows to identify metabolic targets associated with exposures. Using this information, nutritional interventions can be designed toward those targets to mitigate adverse effects or enhance positive effects. We also discuss the potential for this approach in precision nutrition where nutrients/diet can be used to target gene-environment interactions and other subpopulation characteristics. Deriving these “nutrient cocktails” presents an opportunity to modify the effects of exposures for more beneficial outcomes in public health.
Author List
Members of the Exposomics Consortium*
The Exposomics Consortium consists of participants in the NIEHS Catalytic Workshop Series on the Exposome. *Members were required to opt-in to the roster below.
| Name | Institution | Country |
|---|---|---|
| ADAMU, Yau | University of Iowa | United States |
| ADEBAMOWO, Clement (Prof.) | University of Maryland at Baltimore | United States |
| AKHTARI, Farida (Ph.D.) | NIEHS | United States |
| AKHTARI, Farida (Ph.D.) | NIEHS | United States |
| ARGOS, Maria (Ph.D.) | Boston University | United States |
| ARUNACHALAM, Saravanan (Prof.) | University of North Carolina at Chapel Hill | United States |
| BERGER, Kimberly (Ph.D.) | Sequoia Foundation | United States |
| BHUTANI, Jessie | NIH | United States |
| BISSON, William (Ph.D.) | NIEHS | United States |
| CAI, Lu (M.D.,Ph.D.) | University of Louisville | United States |
| CHAO, Mu-rong (Prof.) | Chung Shan Medical University | Taiwan |
| CHATZIIOANNOU, Anastasia Chrysovalantou (Ph.D.) | University of Crete | Greece |
| CHENG, Qiwen | Arizona State University, Tempe Campus | United States |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| CHUNG, Ming Kei (Ph.D.) | Harvard University | United States |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| CLARK, Robert (Ph.D.) | RTI International | United States |
| COHEN HUBAL, Elaine | EPA | United States |
| COOKE, Marcus (Ph.D.) | University of South Florida | United States |
| COSTELLO, Elizabeth | University of Southern California | United States |
| CUI, Yuxia (Ph.D.) | NIEHS | United States |
| DIERICKX, Erin (Ms.) | University of Connecticut | United States |
| DOLINOY, Dana (Ph.D.) | University of Michigan - Ann Arbor | United States |
| DU, Xiuxia (Prof.) | University of North Carolina at Charlotte | United States |
| DUNLOP, Anne (M.D.) | Emory University | United States |
| GAO, Peng (Prof.) | University of Pittsburgh | United States |
| GAULKE, Christopher (Ph.D.) | University of Illinois at Urbana-Champaign | United States |
| GIEBELHAUS, Ryland T. (Mr.) | University of Alberta | Canada |
| GOODRICH, Jesse (Ph.D.) | University of Southern California | United States |
| GRAFANAKI, Katerina (M.D.,Ph.D.) | University of Patras | Greece |
| GULLAPALLI, Rama (M.D.,Ph.D.) | University of New Mexico | United States |
| HABRE, Rima (Sc.D.) | University of Southern California | United States |
| HAIDARI, Ariana | University of Michigan - Ann Arbor | United States |
| HARARI, Homero (Ph.D.) | Mount Sinai School of Medicine | United States |
| HART, Jaime (Sc.D.) | Harvard University | United States |
| HE, Jingxuan | University of Southern California | United States |
| HOLMES, Philip | NCIT | United States |
| HOOD, Darryl B. (Ph.D.) | Ohio State University | United States |
| HOUSE, John (M.D.,Ph.D.) | NIEHS | United States |
| HU, Chiung-wen (Prof.) | Chung Shan Medical University | Taiwan |
| JANKOWSKA, Marta (Ph.D.) | Beckman Research Institute, City of Hope | United States |
| JI, Hong (Ph.D.) | University of California, Davis | United States |
| KANNAN, Srimathik@gmail.com (Ph.D.) | CloudAspirers | United States |
| KONSTANTINOU, Corina (Ms.) | Cyprus University of Technology | Cyprus |
| LAI, Yunjia (Ph.D.) | Columbia University | United States |
| LANGSTON, Mike (Prof.) | University of Tennessee - Knoxville | United States |
| LASALLE, Janine (Ph.D.) | University of California, Davis | United States |
| LIANG, Donghai (Ph.D.) | Emory University | United States |
| LIAO, Jiawen (Ph.D.) | University of Southern California | United States |
| LUO, Jiajun (Ph.D.) | University of Chicago | United States |
| MAKRIS, Konstantinos C. (Prof.) | Cyprus University of Technology | Cyprus |
| MANZ, Katherine | University of Michigan - Ann Arbor | United States |
| MILLER, Gary (Ph.D.) | Columbia University | United States |
| MOTSINGER-REIF, Alison (Ph.D.) | NIEHS | United States |
| OUIDIR, Marion | INSERM | France |
| PAGE, Grier (Ph.D.) | RTI International | United States |
| PAN, Shudi | University of Southern California | United States |
| PARKER, Graham (Ph.D.) | Wayne State University / School of Medicine | Canada |
| PAUL, Kimberly (Ph.D.) | University of California, Los Angeles | United States |
| PELUSO, Alina | DOE | United States |
| PENNING, Trevor (Ph.D.) | University of Pennsylvania | United States |
| PIERCE, Brandon | University of Chicago | United States |
| PRAJAPATI, Nirmala (Ms.) | Universite Paris-Saclay/ INSERM | France |
| QUINTANA, Penelope J E (Ph.D.) | San Diego State University | United States |
| RAJASEKAR, Arcot (raja) (Prof.) | University of North Carolina at Chapel Hill | United States |
| RIDER, Lisa (M.D.) | NIEHS | United States |
| RUDEN, Douglas (Ph.D.) | Wayne State University | United States |
| RUSHING, Blake (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| SCHüSSLER-FIORENZA ROSE, Sophia Miryam (M.D.,Ph.D.) | Standford University | United States |
| SHAH, Ruchir (Ph.D.) | Sciome LLC | United States |
| SHAHRIAR, Mohammad (M.D.) | University of Chicago | United States |
| SHARMA, Pradeep Kumar (Ph.D.) | CSIR-INDIAN INSTITUTE OF TOXICOLOGY RESEARCH | India |
| SOARES, Lissa | State University of New York at Stony Brook | United States |
| SOLIMAN, Ghada (Ph.D.) | City University of New York, Graduate School and University Center | United States |
| STATES, J Christopher (Ph.D.) | University of Louisville | United States |
| STINGONE, Jeanette | Columbia University | United States |
| STURLA IRIZARRY, Savannah (Ms.) | University of Michigan - Ann Arbor | United States |
| SUN, Yangbo | University of Tennessee - Memphis | United States |
| TEITELBAUM, Susan (Ph.D.) | Icahn School of Medicine at Mount Sinai | United States |
| THESSEN, Anne (Ph.D.) | University of Colorado at Denver | United States |
| TONG, Ai Phuong | University of Washington | United States |
| WALKER, Ryan (Ph.D.) | Mount Sinai School of Medicine | United States |
| WANG, Yi (M.D.,Ph.D.) | Canadian Nuclear Laboratories | Canada |
| WHYTE, Kathryn (Ph.D.) | Columbia University | United States |
| WU, K. Lily (Ph.D.) | California Environmental Protection Agency | United States |
| WU, Lang (Prof.) | University of Hawaii - Manoa | United States |
| YUAN, Xin/jean (Ph.D.) | NIH | United States |
| ZHANG, Xinyue (Ph.D.) | Stanford University | United States |
| ZHANG, Qiong | Henry Ford Health System | United States |
| ZHANG, Kai (Ph.D.) | University at Albany | United States |
| ZHAO, Neil | University of Michigan - Ann Arbor | United States |
| ZHU, Yeyi | Kaiser Permanente Northern California Division of Research | United States |